2024
The role of HSD17B3 in male development and health: Disruption of testosterone production and its effects
Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) is known to be the primary enzyme converting androstenedione (A) to testosterone (T) in human and mouse testes. It is therefore important for male development and reproductive health… Junnila, Arttu (2024-10-04)
Androgen receptor therapy resistance in prostate cancer: From the disease model to the mechanisms
Androgens act through the androgen receptor (AR) and are critical regulators of prostate differentiation and function, as well as prostate cancer (PCa) growth and survival. The development of treatment resistance in castration-resistant prostate cancer … Huhtaniemi, Riikka (2024-03-08)
2023
HSD17BS in steroid and lipid metabolism and lipid disorders: the role of HSD17B12 and HSD17B13
Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of fat within hepatocytes, has become the most common chronic liver disease in developed countries. NAFLD is associated with insulin resistance, obesity, … Heikelä, Hanna (2023-10-27)
Computational approaches for single-cell omics and multi-omics data
Single-cell omics and multi-omics technologies have enabled the study of cellular heterogeneity with unprecedented resolution and the discovery of new cell types. The core of identifying heterogeneous cell types, both existing and novel ones, relies on efficient … Adossa, Nigatu Ayele (2023-10-13)
Tools and strategies for RNA-sequencing data analysis
RNA-Sequencing (RNA-seq) has enabled the in-depth study of the transcriptome, becoming the primary research method in the field of molecular biology. The typical aim of RNA-seq is to quantify and detect differentially expressed (DE) and differentially spliced (DS) … Mehmood, Arfa (2023-08-25)
2021
ENDOMET database – A means to identify novel diagnostic and prognostic tools for endometriosis
Endometriosis is a common benign hormone reliant inflammatory gynecological disease that affects fertile aged women and has a considerable economic impact on healthcare systems. Symptoms include intense menstrual pain, persistent pelvic pain, … Gabriel, Michael (2021-12-17)
2018
Modeling and prediction of advanced prostate cancer
Background: Prostate cancer (PCa) is the most commonly diagnosed cancer and second leading cause of cancer-related deaths for men in Western countries. The advanced form of the disease is life-threatening with few options … Laajala, Teemu Daniel (2018-11-16)
Modern methods of evaluating endometriosis
Endometriosis is a common chronic disease, affecting women of reproductive age. Typical symptoms include severe menstrual pain, other pelvic pain symptoms as well as infertility. Adolescent onset of symptoms is common, … Suvitie, Pia (2018-06-08)
Hydroxysteroid (17beta) dehydrogenase 1 expression enhances estrogen action and serves as a potential drug target for reducing estrogen signaling in the uterus and mammary glands
Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is a steroid metabolizing enzyme with a preface for converting the low active estrogen estrone (E1) to highly active estradiol (E2). Accordingly, HSD17B1 is expressed … Järvensivu, Päivi (2018-01-26)
HSD17B12 – an enzyme with a role in embryonic development, normal ovarian function, and cancer
At present, 14 different types of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) enzymes have been characterized. These enzymes differ from each other according to tissue distribution, substrate specificity, subcellular … Kemiläinen, Heidi (2018-01-19)
Outcome of Hsd17b1 gene deletion in ovarian and adipose tissue function: alterations resulting from both HSD17B1 enzyme inhibition and the off-target effect on the Naglu gene
Steroids comprise a group of hormones that are, in the traditional view, secreted by the adrenal cortex, testes and ovaries, as well as the placenta during pregnancy and that reach their target organs via blood circulation. … Jokela, Heli (2018-01-05)
2017
Regulation of gonadal steroid synthesis and reproduction: novel roles of hydroxysteroid (17β) dehydrogenase 1
Estrogens and androgens are critical regulators of several physiological processes, including development and reproduction. In addition, these hormones play key roles in several physiological complications and diseases, … Hakkarainen, Janne (2017-12-15)
Intratumoral androgen biosynthesis in prostate cancer: Evidence from preclinical models and clinical specimens
Androgens regulate the growth and development of normal prostate and prostate cancer. Blocking the production and effects of androgens, either by castration or medication, has been the most efficient strategy for treating … Knuuttila, Matias (2017-09-22)
Ovarian cancer marker HE4 in hormone-related gynecological conditions and diagnosis of ovarian granulosa cell tumors
Ovarian cancer is commonly diagnosed at an advanced stage as the early stages are symptom-free. Despite the development in the fields of surgery and chemotherapy, the prognosis remains poor. In order to … Hallamaa, Marianne (2017-05-12)
2016
Tissue Proteomes: Quantitative Mass Spectrometry of Murine Liver and Ovarian Endometrioma
A human genome contains more than 20 000 protein-encoding genes. A human proteome, instead, has been estimated to be much more complex and dynamic. The most powerful tool to study proteins today is mass … Vehmas, Anni (2016-09-02)
2014
Novel genes and regulatory systems in epididymal differentiation and sperm maturation of the mouse
Mammalian spermatozoa gain their fertilizing ability during maturation in the epididymis. Proteins and lipids secreted into the epididymal lumen remodel the sperm membrane, thereby providing the structure necessary for … Björkgren, Ida (2014-12-12)
2011
Characterization of novel genes predominantly expressed in the epididymis – from genome analyses to genetically modified mice
In mammals, post-testicular sperm maturation taking place in the epididymis is required for the spermatozoa to acquire the abilities required to fertilize the egg in vivo. The epididymal epithelial cells secrete … Turunen, Heikki (2011-11-18)
2010
The role of hydroxysteroid (17-beta) dehydrogenase 2, 7 and 12 enzymes in mouse development
Hydroxysteroid (17-beta) dehydrogenases (HSD17Bs) are a group of enzymes activating or inactivating the ligand signaling through the nuclear receptors. HSD17Bs catalyze the conversion between 17-keto and 17β-hydroxysteroids … Rantakari, Pia (2010-04-23)
Molecular profiling of human endometrium and endometriosis
Endometriosis is a common hormone-dependent gynecological disease leading to severe menstrual and/or chronic pelvic pain with or without subfertility. The disease is defined by the presence of endometrium-like tissue outside … Huhtinen, Kaisa (2010-03-05)
2009
Role of human hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) in steroid-dependent diseases in females –novel indications for HSD17B1 inhibitors. Phenotypic analysis of transgenic mice overexpressing human HSD17B1
Hormone-dependent diseases, e.g., cancers, rank high in mortality in the modern world, and thus, there is an urgent need for new drugs to treat these diseases. Although the diseases are clearly hormone-dependent, changes … Saloniemi, Taija (2009-10-02)