Other Affiliations

• The Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Sweden Senior Research Fellow
• Forendo Pharma Scientific Adviser

Key Academic Merits

• 19 PhD candidates supervised/co-supervised
• Official opponent in 7 academic doctoral dissertations
• 20 Doctoral thesis Reviews
• Referee in more than 15 international scientific journals
• Past and present membership in editorial boards and guest editor in international scientific journals
• Co-founder Forendo Pharma with several international investors (Novo Seeds, Karolinska Development, Innovestor, Novartis Venture Fund, M Ventures, Vesalius Biocapital II Partners, Sunstone Life Science Ventures)

Major Funding

Academy of Finland, The Finnish Cancer Organizations, Sigrid Jusélius Foundation, Novo Foundation, Business Finland, Vetenskaps Rådet (Sweden), Cancer Foundation (Sweden)

Selected Publications

Huhtaniemi R, Sipilä P, Junnila A, Oksala R, Knuuttila M, Mehmood A, Aho E, Laajala TD, Aittokallio T, Laiho A, Elo L, Ohlsson C, Thulin MH, Kallio P, Mäkelä S, Mustonen MVJ, Poutanen M. High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice. iScience. 25:104287 (2022).

Heinosalo T, Rytkönen KT, Saarinen N, Järvensivu P, Damdimopoulou P, Strauss L, Orasniemi S, Horshauge P, Gabriel M, Koskimies P, Ohlsson C, Kronqvist P, Poutanen M. Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice. Int J Mol Sci. 23:4815 (2022).

Rytkönen KT, Faux T, Mahmoudian M, Heinosalo T, Nnamani MC, Perheentupa A, Poutanen M, Elo LL, Wagner GP. Histone H3K4me3 breadth in hypoxia reveals endometrial core functions and stress adaptation linked to endometriosis iScience.25:104235 (2022).

Gabriel M, Fey V, Heinosalo T, Adhikari P, Rytkönen K, Komulainen T, Huhtinen K, Laajala TD, Siitari H, Virkki A, Suvitie P, Kujari H, Aittokallio T, Perheentupa A, Poutanen M.   A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions. Sci Data. 7:284

Sipilä P, Junnila A, Hakkarainen J, Huhtaniemi R, Mairinoja L, Zhang FP, Strauss L, Ohlsson C, Kotaja N, Huhtaniemi I, Poutanen M. The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency. FASEB J. 34:6111-6128 (2020). (2020).

Heinosalo T., Gabriel M., Kallio L., Adhikari P., Huhtinen K., Laajala D., Kaikkonen E., Mehmood A., Suvitie P., Kujari H., Aittokallio T., Perheentupa A., Poutanen M., Human Secreted Frizzled-Related Protein 2, SFRP2, marks endometriosis lesion borders and acts as a canonical WNT signaling agonist promoting proliferation of endometriosis lesions. Human Reprod., 33:817-831 (2018).

Recent Publications